Histone acetyltransferase HAT1 drives malignant progression in lower-grade glioma: reshaping the immune microenvironment and molecular mechanisms

Key Points

• Malignant progression in lower-grade glioma is driven by the histone acetyltransferase HAT1, impacting tumor behavior.
• The study identifies key changes in the immune microenvironment associated with HAT1 expression and tumor growth.
• Analysis of molecular mechanisms highlights HAT1's role in reshaping cellular pathways linked to aggression in glioma.
• These findings suggest targeted therapies may be necessary to address the altered immune landscape driven by HAT1.