March 3, 2026Open Access

Prevalence and risk factors associated with rifampicin-induced cholestasis jaundice among tuberculosis patients in high-incidence setting: A retrospective cohort study

Key Points

Cholestatic jaundice occurred in 1.52% of tuberculosis patients, indicating a significant risk.
Older age and low BMI were identified as key risk factors for developing jaundice.
The observational analysis highlights the need for early liver monitoring among high-risk groups.
Support for individualized management ensures safe and effective treatment of tuberculosis patients.

Abstract

Rifampicin-induced cholestatic jaundice was observed in 1.52% of TB patients. Older age (≥60 years) and low BMI (2) were identified as key risk factors.Early liver monitoring is essential in high-risk groups. Most patients tolerated rifampicin rechallenge, supporting individualized, risk-based management to ensure safe and effective TB treatment.

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Discussion

Authors

Manunchaya Sintusuwan

Piyapan Prueksapanich

Gompol Suwanpimolkul

Journals

SHILAP Revista de lepidopterología

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

Actions

Institutions

Chulalongkorn University

King Chulalongkorn Memorial Hospital

Thai Red Cross Society

References and Citations

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Prevalence and risk factors associated with rifampicin-induced cholestasis jaundice among tuberculosis patients in high-incidence setting: A retrospective cohort study

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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