Ibuprofen-based thiadiazoles as dual tyrosinase/elastase inhibitors: Synthesis, biological evaluation, and molecular modeling

Key Points

• Tyrosinase and elastase inhibition observed with ibuprofen-based thiadiazoles enhances therapeutic potential.
• The biological evaluation indicates significant inhibitory activity against both targets, with rates exceeding 50%.
• Synthesis and molecular modeling techniques were utilized to assess structural relationships and binding affinities.
• These findings may enable further development of therapeutic strategies targeting skin aging and pigmentation issues.