Three-dimensional DNA nanosphere electrochemical biosensor based on the rolling circle amplification reaction of dumbbell shaped ring for the ultrasensitive detection of cancer-related biomarkers

Key Points

• Ultrasensitive detection of cancer-related biomarkers demonstrates efficacy.
• Key evidence includes a detection limit of 0.1 fM for specific biomarkers.
• Employing rolling circle amplification, this method enhances sensitivity through DNA nanosphere design.
• Further validation in clinical settings is necessary, emphasizing the need for real-world applicability.