Causal association between gut microbiota and osteonecrosis in European populations: a two-sample Mendelian randomization analysis

Key Points

• Gut microbiota appears to be causally associated with osteonecrosis, highlighting a novel risk factor.
• A Mendelian randomization analysis using genetic data from European populations supports this link.
• The findings suggest that interventions targeting gut microbiota may help in preventing osteonecrosis.
• Future research is necessary to explore the underlying mechanisms and confirm these findings.