HSP72 alleviates heat stress-induced oxidative damage in boar Sertoli cells through modulating the AGE-RAGE/NOX4/NF-κB axis

Key Points

• HSP72 alleviates oxidative damage in Sertoli cells under heat stress—key for male fertility.
• Found that levels of NOX4 and NF-κB decrease when HSP72 is present during heat stress exposure.
• Analysis of Sertoli cell responses to heat stress highlights the importance of the AGE-RAGE pathway.
• Findings may enable new strategies to protect male reproductive health during temperature extremes.