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DHODH turns cytosolic, yet cells keep growing | Synapse
March 3, 2026
DHODH turns cytosolic, yet cells keep growing
OV
Olivia Vidal-Cruchez
Northwestern University
IB
Issam Ben-Sahra
Northwestern University
Puntos clave
Cell growth continues even with cytosolic localization of DHODH, underscoring metabolic flexibility.
Changes in dihydroorotate dehydrogenase localization do not inhibit cellular proliferation, indicating resilience.
Analysis of cellular behavior revealed metabolic pathways adapting to altered DHODH positioning.
Support for metabolic adaptability reflects broader implications for cellular responses to localization shifts.
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Vidal-Cruchez et al. (Tue,) studied this question.
synapsesocial.com/papers/69a7617fc6e9836116a2f82f
https://doi.org/https://doi.org/10.1038/s42255-026-01466-3
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