Single-Cell Analysis of Chemotherapy-induced Remodeling Reveals CD276-driven Basal-like Chemoresistance in Pancreatic Cancer

Key Points

• Chemoresistance was linked to CD276 in pancreatic cancer cells, indicating a key player in treatment failure.
• Analysis revealed that single-cell techniques demonstrated a unique tumor microenvironment involved in remodeling.
• Characterization involved investigating the mechanisms underlying treatment resistance through single-cell analysis.
• These findings support the potential for targeted therapies against CD276 in resistant pancreatic cancer.