Targeting Warburg effect: involvement of lactate transporter MCT1 and its chaperone in cancer cell killing by 18β-glycyrrhetinic acid

Key Points

• Cancer cell killing is maximized by targeting the Warburg effect, enhancing therapeutic efficacy.
• Key findings show a significant increase in the apoptosis rate associated with high MCT1 levels.
• Assessment using cellular assays identifies MCT1 and its chaperone as critical mediators in response to 18β-glycyrrhetinic acid.
• Highlights a potential new treatment strategy for cancer; implications warrant further clinical exploration.