An antibacterial microneedle with chemodynamic therapy triggered by microwave thermal effect for diabetic infected wound healing

Fe3O4@AIPH microneedle patch exhibit excellent antibacterial and anti-inflammatory properties under microwave irradiation, effectively accelerating the healing process of diabetic infected wounds. Additionally, both ferrite and microwave therapy devices have received FDA approval for medical purposes, offering potential for the clinical application of microwave-responsive Fe3O4@AIPH microneedle patches. Long-term microwave-assisted therapy may carry the potential risk of excessive skin temperatures, capable of alleviation through improvement in material microwave absorption efficiency or adoption of a segmented treatment strategy.