3D in vitro co-culture disc for assessing cancer invasiveness in the tumor stroma microenvironment

Key Points

• Cancer invasiveness was effectively assessed using a 3D co-culture system in vitro, showcasing significant potential for research applications.
• The co-culture disc system revealed differences in invasiveness, with stroma interactions influencing tumor behavior, suggesting complex biological interactions.
• Assessment implemented an innovative in vitro assay to simulate the tumor microenvironment, capturing the dynamics of cancer cell interactions.
• This model highlights the potential for developing targeted therapies, though further validation in vivo may be necessary to confirm findings.