Oligodendrocyte dysfunction in major depressive disorder: Mechanistic insights and emerging therapies

Key Points

• Oligodendrocyte dysfunction is linked to major depressive disorder, affecting brain function and mood regulation.
• Key evidence shows alterations in oligodendrocyte activity are prevalent in patients with major depressive disorder.
• Analysis of current therapies reveals new treatments are emerging to target oligodendrocyte dysfunction effectively.
• Highlighting connections between oligodendrocytes and depression opens new pathways for developing therapies.