Discovery of small-sized tris-aryl imidazoles as bifunctional ligands for c-Myc and KRAS G-quadruplexes

Key Points

• Small-sized tris-aryl imidazoles effectively bind to c-Myc and KRAS G-quadruplexes, enhancing their stability.
• Research demonstrates high binding affinity with a dissociation constant in the low micromolar range.
• Study involved structural analysis through spectroscopy to characterize ligand interactions with G-quadruplexes.
• Findings indicate potential for targeting c-Myc and KRAS in cancer therapy.