Design and in silico characterization of a novel chimeric P53–SOG1 fusion protein for enhanced dna damage response and tumor suppression

Key Points

• The chimeric P53–SOG1 fusion protein improves the DNA damage response mechanism, enhancing tumor suppression.
• Characterization reveals significant mutations by combining functionalities of p53 and sog1 in addressing DNA repair.
• In silico analysis suggests the fusion may increase resilience against tumorigenesis and cellular stress.
• Potential applicability in cancer treatments highlights the need for further experimental validation.