Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2

Key Points

• Immunity to SARS-CoV-2 is impaired by deleterious variants in the RB1CC1 gene, affecting autophagic pathways.
• The study found a significant association between specific RB1CC1 variants and reduced immune response.
• Analysis focused on the role of the RB1CC1 autophagy-related gene and its impact on viral immunity.
• Findings highlight the importance of autophagy in protecting against SARS-CoV-2, with potential therapeutic implications.