This is the case of a 49-year-old female who presented with a chronic, irritated lesion on her left upper eyelid. Following wide local excision, histopathological examination revealed a well-circumscribed lesion consistent with apocrine adenocarcinoma (AC). AC is a rare malignant tumor arising from apocrine sweat glands, typically found in the axillary and anogenital regions. Occasionally, it can present on the eyelid arising from specialized apocrine structures such as Moll’s glands.. AC of the eyelid is often misdiagnosed due to its clinical resemblance to benign conditions such as chalazion, potentially delaying appropriate treatment. Diagnosis relies heavily on histopathology and may be supported by immunohistochemical markers. Wide local excision remains the mainstay of treatment, while radiation and chemotherapy may be considered in invasive cases. Recurrence and metastasis rates are notable, with lymph node involvement significantly impacting prognosis. Clinicians should maintain a high index of suspicion for atypical or persistent eyelid lesions to ensure timely diagnosis and optimal outcomes.
Bowman et al. (Fri,) studied this question.