Distinct serum metabolic profiles with supportive diagnostic value in differentiating tuberculosis and Mycobacterium avium complex pulmonary disease

Key Points

• Alterations in sphingoid base lipids and 2-HG serve as potential biomarkers, enhancing diagnostic capabilities for tuberculosis and MAC pulmonary disease.
• The discriminative potential of metabolic profiles was highlighted, showcasing significant differences between the two mycobacterial diseases.
• Assessment involved identifying specific metabolites associated with tuberculosis and MAC pulmonary disease, enabling clearer differentiation.
• These findings indicate that specific serum metabolites may enable earlier diagnosis, but further validation in clinical settings is necessary.

Abstract