Does QT dispersion (> 50 ms) and corrected QT interval predict mortality and the need for mechanical ventilation in adult septic patients?
40 adult patients admitted with diagnosis of sepsis at Critical Care Department at Kasr Al-Ainy Hospital and at ICU unit at Ahmed Maher Teaching Hospital, along with 20 healthy participants included as controls.
Measurement of QT dispersion (QTD) and corrected QT interval (QTc) via 12-lead ECG monitoring for 7 consecutive days
20 healthy participants included as controls to measure normal QTc and QTD
Mortalityhard clinical
In adult septic patients, the development of QT dispersion > 50 ms during hospitalization is strongly associated with increased mortality and the need for mechanical ventilation.
Sepsis is one of the leading post-surgical or post-traumatic complications in today’s hospitals. This pervasive condition is the major cause of morbidity and mortality in intensive care units worldwide, as well as the leading cause of death in non-coronary patients. To study QT dispersion (QTD) and corrected QT interval (QTc) in septic patients in relation to mortality. A prospective observational cohort study including 40 adult patients admitted with diagnosis of sepsis at Critical Care Department at Kasr Al-Ainy Hospital and at ICU unit at Ahmed Maher Teaching Hospital. They were monitored with 12-lead ECG for 7 consecutive days for QTc and QTD measurement. QT intervals were measured in milliseconds (ms), and positive QTD was defined as > 50 ms. Twenty healthy participants were included as controls to measure normal QTc and QTD. It was found that 27.5% of the studied population developed arrhythmias and 60% died. QTD developed in 37.5% of patients during hospitalization and was significantly associated with mortality (p-value 50 ms) developing during hospitalization was strongly associated with mortality and need for mechanical ventilation in septic patients. These findings suggest QTD may have prognostic value in sepsis; however, the small sample size and single-center design limit generalizability. Larger, multicenter prospective studies with automated QT measurement protocols are needed to validate QTD as a clinical prognostic tool in sepsis.
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Ibrahim Mohamed Attia Mahmoud
Hassan Khaled Nagy
Ahmed Mohamed Elsayed Selim
SHILAP Revista de lepidopterología
The Egyptian Journal of Critical Care Medicine
Cairo University
World Health Organization - Egypt
Ministry of Communication and Information Technology
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Mahmoud et al. (Sun,) studied this question.
www.synapsesocial.com/papers/69a765a4badf0bb9e87d9db3 — DOI: https://doi.org/10.1007/s44349-025-00037-x