March 3, 2026

Visualization of Urinary Tract Infection in a Mouse Model Using Bioluminescence

Key Points

Infection progression is monitored using bioluminescence imaging, providing real-time insights into bacterial load.
The study tracks E. coli behavior as it adheres and replicates within the bladder in mice.
Visual evidence shows bacterial interactions within the host, enhancing understanding of urinary tract infections.
The findings may guide future treatments, although results are based on a mouse model requiring further validation.

Abstract

Source: Luyts, N., et al. Longitudinal Follow-Up of Urinary Tract Infections and Their Treatment in Mice using Bioluminescence Imaging. J. Vis. Exp. (2021).This video demonstrates the induction and tracking of urinary tract infection in a mouse model using bioluminescent E. coli injected into the bladder, where bacterial adhesion, invasion, and intracellular replication occur. The emitted light from the bioluminescent operon serves as a real-time marker of bacterial load during infection progression.

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www.synapsesocial.com/papers/69a765bcbadf0bb9e87da3d4 — DOI: https://doi.org/10.3791/24359

Visualization of Urinary Tract Infection in a Mouse Model Using Bioluminescence

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