Can [18F]FOL PET imaging detect activated macrophages and predict left ventricular systolic function worsening in experimental myocardial infarction?
Experimental myocardial infarction model
[18F]FOL PET imaging
Detection of FR-β expression (marker of activated macrophages) and its association with left ventricular systolic functionsurrogate
[18F]FOL PET imaging can successfully detect activated macrophages post-MI, with early FR-β expression predicting worsening left ventricular systolic function.
18FFOL PET detects expression of FR-β, a marker of activated macrophages after MI. FR-β expression peaks early and remains elevated up to 3 months post-MI. Early FR-β expression is associated with worsening of left ventricular systolic function.
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Imran Iqbal
Heidi Liljenbäck
Putri Andriana
Journal of Nuclear Cardiology
Purdue University West Lafayette
University of Turku
Turku University Hospital
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Iqbal et al. (Sun,) studied this question.
www.synapsesocial.com/papers/69a765bdbadf0bb9e87da404 — DOI: https://doi.org/10.1016/j.nuclcard.2026.102653