Electronic, steric, and solvent determinants of COS absorption–desorption–hydrolysis by secondary amines: A descriptor-based quantitative study

Key Points

• COS absorption demonstrates a critical dependence on electronic and steric factors of secondary amines, influencing solubility and reactivity.
• Desorption rates were significantly affected by solvent polarity and steric hindrance, revealing important interactions in COS behavior.
• The study employs a descriptor-based approach to quantitatively assess how varying conditions affect COS hydrolysis rates.
• Understanding these determinants may enable the development of more effective secondary amines for industrial applications.