Comprehensive profiling of the human tear fluid miRNome using small RNA sequencing

Key Points

• The study establishes a high-resolution reference profile of the human tear fluid mirnome, indicating its functional significance.
• A diverse array of miRNAs was identified, with findings highlighting the stability of these molecules over time.
• Assessment using small RNA sequencing reveals essential baseline data for future studies on disease-associated alterations of tear miRNAs.
• Demographic associations suggest intriguing patterns, although larger and more powered studies are needed to confirm these observations.

Abstract