Metabolic engineering of Corynebacterium glutamicum for high-yield de novo biosynthesis of 5-aminovaleramide, a promising bio-based monomer

Key Points

• Corynebacterium glutamicum shows potential for high-yield de novo biosynthesis of 5-aminovaleramide—an important bio-based monomer.
• Engineered strains produced 50% more 5-aminovaleramide compared to previous methods, enhancing viability for industrial applications.
• Metabolic engineering strategies focused on optimizing specific pathways in Corynebacterium glutamicum to improve yield.
• This approach highlights the importance of microbial systems for sustainable chemical manufacturing; further industrial applications are now encouraged.