Integrating RFantibody and molecular dynamics to discover high-affinity Nanobody inhibitors targeting dengue virus NS3 protease

Key Points

• High-affinity nanobody inhibitors effectively target dengue virus NS3 protease, showing promising results.
• The top inhibitors achieved an affinity of 10 nM, indicating strong potential for treatment.
• Integration of RFantibody and molecular dynamics was used to identify promising nanobody candidates.
• Findings highlight the need for further testing to validate efficacy in living systems.