Novel association of HLA-DQA1 and HLA-DPB1 alleles with acute myeloid leukemia susceptibility in (Central Asian) Kazakhstani population: A case-control study

Key Points

• Acute myeloid leukemia susceptibility is significantly associated with specific HLA-DQA1 and HLA-DPB1 alleles.
• Individuals with certain HLA-DQA1 alleles show a notably higher risk of developing acute myeloid leukemia.
• Case-control study analyzed genetic variations in Kazakhstani individuals with acute myeloid leukemia and healthy controls.
• Findings suggest that genetic predisposition may play a crucial role in leukemia risk in this population.