Development of an integrated liquid chromatography-tandem mass spectrometry method for comprehensive analysis of the one-carbon metabolome and DNA/RNA methylation in plasma

Puntos clave

• Comprehensive analysis reveals significant changes in the one-carbon metabolome and its relation to methylation levels.
• The method utilizes liquid chromatography coupled with tandem mass spectrometry to analyze various metabolites in plasma.
• This advanced approach highlights potential metabolic markers that could be linked to health conditions based on plasma samples.
• Findings may indicate new avenues for understanding metabolic pathways, with further research needed for clinical implications.