High Mobility Group Protein B1 and its downstream elements, syntaxins, contribute to temporal tight junction assembly in a human keratinocyte cell line

Key Points

• Tight junction assembly is influenced by high mobility group protein B1 and syntaxins, indicating a critical role in cellular structure.
• Detailed observations show that changes in protein activity facilitate temporal assembly within keratinocyte lines.
• Analysis of protein interactions reveals how syntaxins impact the dynamics of tight junction formation over time.
• These findings suggest potential pathways for therapeutic interventions targeting skin barrier functions.