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March 3, 2026Cytotherapy0 citationsOpen Access

Bovine mesenchymal stromal and induced pluripotent stem cell secretomes exhibit regenerative, but not antimicrobial, activity in vitro

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RHRebecca M. HarmanKOKelly A. OxfordCECristina L. Esteves

Key Points

  • Regenerative activity is observed from both bovine mesenchymal stromal cells and induced pluripotent stem cells.
  • The study emphasizes that while both secretomes exhibit promising regenerative potential, they do not show antimicrobial activity.
  • Assessment of stem cell secretomes reveals key insights into their effects on tissue regeneration without providing antimicrobial benefits.
  • Findings highlight the need for developing additional strategies to induce antimicrobial effects alongside regenerative activity.

Abstract

Although the therapeutic potential of bovine stem cell secreted factors tested in this study is promising in terms of tissue regeneration, additional strategies must be employed to induce an antimicrobial effect.

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Cite This Study

Harman et al. (2026) studied this question.

synapsesocial.com/papers/69a7665abadf0bb9e87dcad8https://doi.org/10.1016/j.jcyt.2026.102100
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