The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Appendix S1 Supplementary methods. Table S1 Subject demographics of 26 cases of isolated cerebral ventriculomegaly included in study. Table S2 Fetal magnetic resonance imaging parameters from the two study institutions. Table S3 Sulcal position pattern similarity indices of age-appropriate vs delayed neurodevelopment groups compared with matched normal template brains. Figure S1 Flowchart showing case selection and exclusion through imaging analysis process. Figure S2 Distribution of site-specific study data in regional volumetric analysis of left cortical plate (a) and sulcal position pattern similarity analysis compared with matched normal template brains of left whole sulcal pattern (b) in fetuses with isolated ventriculomegaly who presented with delayed vs age-appropriate neurodevelopment at 2 years of age. Data points derived from Jikei University (JU) cases (JU11 and JU13) are labelled with arrows. The remaining data points were derived from cases at Tufts Medical Center. Distribution of JU datapoints appeared not to cause site effects, as they are evenly distributed between the delayed and age-appropriate neurodevelopment groups. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Reid et al. (Mon,) studied this question.