Cisplatin disrupts OCT1-DNMT1-piRNA epigenetic regulatory axis to suppress GAB2-mediated aggressiveness in OSCC

Key Points

• Cisplatin treatment significantly reduced GAB2 expression, impacting tumor aggressiveness in oral squamous cell carcinoma.
• Reduction in aggressiveness was linked to the disruption of the OCT1-DNMT1-piRNA epigenetic regulatory axis.
• Analysis focused on oral squamous cell carcinoma (OSCC) cells to understand treatment effects on aggressiveness.
• Research highlights the potential of targeting epigenetic pathways for therapeutic strategies against OSCC.