Impairment of the non-catalytic subunit Dpb2 of DNA Pol ε results in increased involvement of Pol δ on the leading strand

Key Points

• Increased involvement of polymerase delta on the leading strand occurs due to impairment of the Dpb2 subunit.
• The functional role of the Dpb2 subunit is crucial for maintaining replication fidelity in DNA polymerase epsilon.
• Assessment of enzyme activity reveals significant shifts in polymerase delta's role under impaired conditions.
• These findings may indicate novel regulatory mechanisms affecting DNA synthesis and replication fidelity.