Combined effects of quercetagetin and D-amino acids against Pseudomonas aeruginosa: Anti-quorum sensing, antibacterial, and antibiofilm activities

Key Points

• Quercetagetin and d-amino acids effectively inhibit quorum sensing in Pseudomonas aeruginosa, helping to prevent biofilm formation.
• Combination therapy shows significant antibacterial activity against Pseudomonas aeruginosa, notably reducing its growth.
• Evaluation includes in vitro experiments assessing anti-quorum sensing, antibacterial, and antibiofilm properties.
• Further studies are needed to confirm efficacy in clinical settings and to understand potential resistance mechanisms.