Persistent adverse effects of cancer treatments on mental health, fatigue, and sleep disturbances in breast cancer survivors

Breast cancer is the most diagnosed cancer worldwide, affecting one in four women diagnosed with cancer. Cancer treatments, particularly chemotherapy, can adversely impact mental health, contributing to increased stress, anxiety, depression, fatigue, and poor sleep quality. This study investigated the long-term psychological effects of cancer treatment among breast cancer survivors and explored interactions between these factors. We recruited Canadian women aged 30 to 65 with a history of breast cancer who were at least 6-months post-treatment (n = 49) and age-matched control participants (n = 44). Participants provided demographic and health information and completed online questionnaires assessing stress, depression, trait and state anxiety, fatigue, sleep quality, and physical activity. Breast cancer survivors reported significantly higher levels of stress (p = .004), depression (p 0.05), most mental health factors were correlated with each other in both groups (p’s < 0.05). Our findings enhance understanding of the long-term mental health effects of cancer treatment in breast cancer survivors, providing strong evidence that breast cancer survivors continue to experience significant psychological challenges – including stress, anxiety, depression, fatigue, and sleep disturbances. Given these persistent challenges, it is critical to incorporate comprehensive mental health assessments into cancer survivorship plans to identify psychological concerns and inform treatment strategies that address the interconnectedness of these issues.