Clinical benefits of prolonged versus standard prone positioning in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome: A systematic review, meta-analysis, and trial-sequential analysis

Key Points

• Prolonged prone positioning improves clinical outcomes in patients with acute respiratory distress syndrome.
• The odds ratio for clinical improvement was 1.64 based on a meta-analysis of multiple studies.
• Systematic review and trial-sequential analysis were utilized to assess the effectiveness of prone positioning.
• Evidence supports the potential for prolonged positioning to enhance recovery in severely ill COVID-19 patients.