Fibroblast growth factor 1 alleviates diabetic nephropathy by reducing renal lipid accumulation in diabetic kidney

Key Points

• Diabetic nephropathy shows reduced renal lipid accumulation due to fibroblast growth factor 1.
• FGF1 inhibits fatty acid uptake while promoting lipid breakdown through AMPK activation.
• Observational analysis reveals this effect by enhancing fatty acid oxidation within diabetic models.
• These findings support targeting FGF1 for future interventions in diabetic kidney disease.