March 3, 2026Open Access

Exosomes derived from bone marrow mesenchymal stem cells attenuate OGD/R-induced apoptosis in PC-12 cells via activation of the PI3K/AKT pathway

Key Points

Reduced apoptosis was observed in PC-12 cells, indicating the effectiveness of exosomes.
Exosomes derived from bone marrow mesenchymal stem cells significantly mitigate apoptosis under specific conditions.
Assessment utilized oxygen-glucose deprivation/reperfusion to evaluate the impact of exosome treatment.
Findings imply a potential therapeutic role for exosomes, though enhancement strategies may require further exploration.

Abstract

Exosomes derived frvom BMSC effectively inhibitedp aupoptposis induced by OpGD/R through uactivation of the PI3K/Akt. Although HP significantly enhanced the secretion of exosomes from BMSC, it did not improve the therapeutic efficacy of these exosomes when administered at an equivalent dosage.

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Journal of Stem Cells and Regenerative Medicine

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Exosomes derived from bone marrow mesenchymal stem cells attenuate OGD/R-induced apoptosis in PC-12 cells via activation of the PI3K/AKT pathway

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Abstract

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