Cerebrovascular reactivity (CVR), the ability of cerebral blood vessels to dilate or constrict in response to a vasoactive stimulus, is a clinically meaningful measure of cerebrovascular health. Head motion and other noise sources substantially impact CVR quality, particularly in clinical populations. In this study, we evaluated multi-echo fMRI techniques, including optimal combination of echoes (ME-OC) and multi-echo independent component analysis (ME-ICA), for improving CVR quality relative to single-echo fMRI in participants with stroke. In a breath-hold fMRI dataset, ME-OC significantly improved CVR quality metrics and reduced the percentage of negative CVR values in normal-appearing gray and white matter (pp<0.05). These findings demonstrate that multi-echo fMRI can improve CVR estimation in clinical populations, particularly in low signal-to-noise datasets, enhancing the feasibility of CVR analyses in stroke studies and allowing for better visualization of stroke-related CVR deficits.
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Rebecca G. Clements
Fatemeh Geranmayeh
Niamh Parkinson
Imperial College London
Northwestern University
Imperial College Healthcare NHS Trust
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Clements et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69a767dcbadf0bb9e87e2ac6 — DOI: https://doi.org/10.64898/2026.02.03.703581