How microorganisms respond to single and binary antibiotic exposure: Focusing on detoxification, nitrogen, phosphorus, and cell metabolism mechanisms

Key Points

• Microorganisms exhibit varied detoxification pathways when exposed to single or binary antibiotics, revealing adaptation strategies.
• Key mechanisms include the modulation of nitrogen and phosphorus metabolism, which is critical in antibiotic response.
• Assessment of metabolic changes shows that different antibiotics invoke distinct cellular responses, impacting survival.
• Understanding these interactions highlights the challenges in treating infections and the need for targeted antibiotic therapies.