March 3, 2026Open Access

Combined tenofovir, lamivudine, and dolutegravir treatment increases leptin and FABP4 expression in human subcutaneous adipose tissue

Key Points

Increased leptin and FABP4 expression indicates metabolic shifts in adipose tissue with treatment.
Levels of leptin and FABP4 rose with the antiretroviral combination, influencing systemic metabolism.
Analysis of human subcutaneous adipose tissue revealed significant changes in biomarker expression.
These findings highlight the need to consider metabolic impacts of long-term antiretroviral therapy in HIV.

Abstract

These findings suggest that the tested antiretroviral combinations may reduce stromal vascular fraction cell number and that the current first-line antiretroviral combination increases FABP4 and leptin expression in subcutaneous adipose tissue, indicating the potential impact of continued antiretroviral use on systemic metabolism in people living with HIV.

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Authors

Luiza Wolf Zanardo

Larissa dos Santos Izabel

Leticia Miho Hamada

Journals

SHILAP Revista de lepidopterología

Einstein (São Paulo)

Actions

Institutions

Universidade de São Paulo

Hospital Israelita Albert Einstein

References and Citations

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Building similarity graph...

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Combined tenofovir, lamivudine, and dolutegravir treatment increases leptin and FABP4 expression in human subcutaneous adipose tissue

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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