PLS3-AS1 promotes colorectal cancer progression and radioresistance by sustaining NF-κB signaling

Key Points

• PLS3-AS1 enhances cancer progression and radioresistance, indicating a significant shift in disease outcome.
• A growth delay of 34% in tumor size was observed in PLS3-AS1 silenced models compared to controls.
• Analysis of colorectal cancer tissues showed increased NF-κB signaling in tumors versus non-tumor tissues.
• This highlights the need for targeted therapies addressing PLS3-AS1 signaling to improve patient outcomes.