Seasonal fluctuations in ambient particulate matter2.5 exposure differentially regulate JAK2/STAT3 signaling in never smoking rural and urban cohorts

Key Points

• JAK2/STAT3 signaling is differentially regulated by seasonal ambient particulate matter exposure among rural and urban cohorts, affecting immune response.
• Significant fluctuations were observed, with particulate matter levels varying substantially between seasons and settings.
• Observational analysis across rural and urban communities explored how particulate matter exposure impacts immune signaling pathways.
• These findings highlight the need for targeted interventions to mitigate particulate matter exposure's effects, especially in vulnerable populations.