New thermodynamic aspects and speciation properties of the angiotensin-converting enzyme inhibitor drug, lisinopril with Cu2+, Zn2+, Ca2+, Mg2+ in sodium chloride aqueous solution

Key Points

• Lisinopril shows significant interaction with metal ions Cu2+, Zn2+, Ca2+, and Mg2+ in sodium chloride solutions.
• The thermodynamic analysis highlights the binding stability and speciation of lisinopril with these metal ions, crucial for its activation.
• Evaluation through experimental methods reveals the effects of sodium chloride on the binding characteristics of lisinopril, enhancing understanding of its behavior.
• These insights may aid in improving therapeutic strategies involving lisinopril, suggesting a need for further exploration in clinical settings.