Synergistic Antibacterial Activity of Quercetin-Functionalized Magnetic Nanoparticles Combined with Ciprofloxacin on Pathogenic Pseudomonas Aeruginosa Via Targeting Virulence, Efflux Pump, and Adhesion-Associated Genes and Molecular Docking Analysis

Key Points

• Quercetin-functionalized magnetic nanoparticles enhance the antibacterial activity of ciprofloxacin against Pseudomonas aeruginosa.
• The combination notably targets virulence, efflux pump, and adhesion-associated genes, leading to effective treatment.
• Assessment using molecular docking analysis provides insights into the interactions between nanoparticles and bacterial components.
• Supports the development of combination therapies aimed at improving treatment outcomes against resistant bacterial infections.