IL-18 promotes pancreatic fibrosis via release of IL-4 from pancreatic stellate cells and induces macrophage M2 polarization

Key Points

• Pancreatic fibrosis is significantly promoted by IL-18 through IL-4 release.
• The conversion to macrophage M2 polarization was observed with notable changes in cytokine expression.
• Analysis focused on pancreatic stellate cells indicating their role in fibrosis development.
• This highlights a potential therapeutic target for managing pancreatic fibrosis and inflammation.