Fermentation optimization reveals multi-level metabolic regulation of antifungal lipopeptides in Bacillus velezensis YTQ3 for enhanced postharvest biocontrol

Key Points

• Enhanced antifungal activity was achieved through optimized fermentation conditions, leading to improved biocontrol efficacy.
• Lipopeptides produced showed significant antifungal properties, with optimal conditions increasing yields by over 50%.
• Observational analysis of fermentation effects on metabolic regulation revealed pathways critical for lipopeptide synthesis.
• Findings suggest that fermentation optimization may enable more effective postharvest treatments, reducing crop losses.