Genomic characteristics and risk factor analysis of carbapenem-non-susceptible Pseudomonas aeruginosa causing bacteremia in a tertiary hospital (2014–2023)
Retrospective analysis identifies risk factors and resistance mechanisms in CnSPA bloodstream infections, highlighting clinical implications.
Key Points
This research aims to analyze the genomic characteristics and clinical risk factors related to carbapenem-non-susceptible Pseudomonas aeruginosa causing bacteremia.
Retrospective analysis of 52 CnSPA isolates from bloodstream infections from 2014 to 2023
Use of whole-genome sequencing to identify resistance genes and mutations
Integration of clinical data to identify mortality risk factors and polymicrobial infections
Characterization of serotypes, sequence types, and genetic relationships
High resistance to imipenem (98.1%) and other antibiotics, but susceptibility to colistin
Diverse antimicrobial resistance genes and mutations indicated non-carbapenemase resistance mechanisms
Thirty-six distinct sequence types identified, including high-risk clones
Mortality rate of 38.5% with prior carbapenem exposure, organ failure, and prolonged ventilation as independent predictors of death