Background: Migraine is accompanied by several associated symptoms such as nausea, vomiting, photophobia and phonophobia. Aims: The aim of the study was to compare the efficacy of rizatriptan, suzatriptan and conventional therapy (oral paracetamol 500 mg, metoclopramide 10 mg, flunarizine10 mg and alprazolam 0.25 mg) on the associated symptoms of migraine. Materials and Methods: Patients with chronic migraine attending the neurology outpatient department and willing to provide written informed consent were enrolled in this study. A history of migraine-associated symptoms, such as nausea, vomiting, phonophobia or photophobia, was recorded, and patients were allocated into three groups receiving rizatriptan, sumatriptan and conventional therapy. At follow-up after 24 h, improvement in associated symptoms (at 2 h) was noted. Using GraphPad Software, the Chi-square test was applied to assess statistical differences, and P < 0.05 was considered statistically significant. Results: A total of 150 patients completed the study. The improvement in nausea and vomiting at 2 h post-dose was significantly greater ( P = 0.005 and 0.026) with conventional therapy, whereas photophobia and phonophobia were better relieved by rizatriptan, although statistically insignificant. Conclusions: Conventional therapy was significantly more effective in treating disabling associated symptoms of migraine in this study.
Kushwah et al. (Thu,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: