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March 4, 2026Organic Letters0 citations

Chemodivergent Accesses to Hetero-Bicyclo3.3.1nonenes

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YLYue LiHWHao WeiJXJiayi Xu

Key Points

  • The study aims to develop methods for constructing two distinct types of bicyclic compounds using chemodivergent annulations.
  • Utilized sterically controlled and rare-earth-catalyzed reactions.
  • Performed (3 + 3) annulations between enamines and Achmatowicz rearrangement products.
  • Synthesis of enantiopure products from enantiopure starting materials.
  • Successfully constructed 7-oxa-2-azabicyclo[3.3.1]non-3-enes and 3-oxabicyclo[3.3.1]non-6-enes.
  • Achieved efficient production of highly functionalized bicyclic scaffolds.
  • Demonstrated the synthesis of enantiopure products.

Abstract

Harnessing sterically controlled and rare-earth-catalyzed chemodivergent (3 + 3) annulations between enamines and Achmatowicz rearrangement products (ARPs), we provide practical methods for efficiently constructing two types of highly functionalized, three-dimensional, and rigid bicyclic scaffolds─7-oxa-2-azabicyclo3.3.1non-3-enes and 3-oxabicyclo3.3.1non-6-enes. Enantiopure products are also synthesized from readily accessed enantiopure ARPs.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69a7ccc3d48f933b5eed8950https://doi.org/10.1021/acs.orglett.6c00098
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