Penile metastasis from urothelial carcinoma (UC) is rare, typically indicating advanced disease with poor prognosis. Isolated penile involvement is exceptionally uncommon and may permit curative intent. A 67-year-old male with a history of UC treated with radical cystectomy presented 10 months post-cystectomy with penile shaft nodules and priapism. Positron emission tomography–computed tomography revealed isolated metastases to the corpora cavernosa, spongiosum and periurethral tissue without systemic dissemination. Total penectomy with urethrectomy achieved negative margins, revealing UC with lymphovascular invasion. Cisplatin-based adjuvant chemotherapy was administered. At the 10-month follow-up, the patient remained recurrence-free. Although rare, isolated penile metastasis from UC may warrant aggressive local resection combined with systemic therapy to achieve favourable outcomes. This case underscores the importance of early detection and multidisciplinary management of metastatic UC.
Rahar et al. (2026) studied this question.