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March 4, 2026The Journal of Infectious Diseases0 citations

Severe Lower Respiratory Tract Infection From Human Bocavirus Monoinfection

Severe Lower Respiratory Tract Infection in Patients With Human Bocavirus Monoinfection in Southeast China

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Population

Children with Human Bocavirus (HBoV) monoinfection and lower respiratory tract infection (LRTI)

Design

Other

Key result

High HBoV DNA load, elevated IFN-γ, neutrophilia, and VP1_L40S variant are linked to severe lower respiratory tract infections in children with HBoV monoinfection.

Authors

LLLuona LinXCXin CongWLWei Li

Discussion

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Overview

May warrant closer monitoring in HBoV monoinfection; extends evidence on viral and host inflammatory determinants of severity.

Key Points

  • Investigate the impact of human bocavirus (HBoV) monoinfection on severe lower respiratory tract infections (LRTI) in children in Southeast China.
  • Analyzed cases of children with confirmed HBoV monoinfection.
  • Measured DNA load, IFN-γ levels, and neutrophil counts.
  • Identified viral variants present in patients.
  • High DNA load observed in patients correlates with severe LRTI.
  • Elevated IFN-γ levels and neutrophilia were significant findings.
  • The viral VP1_L40S variant was linked to worse disease outcomes.

Structured PICO

P
Population
Children with Human Bocavirus (HBoV) monoinfection and lower respiratory tract infection (LRTI)
O
Outcome
Severe disease outcomes / critical LRTI

High DNA load, elevated IFN-γ levels, neutrophilia, and the viral VP1_L40S variant are associated with severe lower respiratory tract infection in children with HBoV monoinfection.

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Cite This Study

Lin et al. (2026) studied this question. High HBoV DNA load, elevated IFN-γ, neutrophilia, and VP1_L40S variant are linked to severe lower respiratory tract infections in children with HBoV monoinfection.

synapsesocial.com/papers/69a7cce8d48f933b5eed8d24https://doi.org/10.1093/infdis/jiag024
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Human Bocavirus Infection in Turkish Children2025
  2. 2Distinctive clinical features of human bocavirus in children younger than 2 years2010 · 49 citations
  3. 3High Viral Load of Human Bocavirus Correlates with Duration of Wheezing in Children with Severe Lower Respiratory Tract Infection2012 · 61 citations
  4. 4Human bocavirus-1 infection in hospitalized pediatric patients with acute respiratory tract infections2025 · 8 citations
  5. 5Detection of human bocavirus in children with acute respiratory tract infections in Lanzhou and Nanjing, China.2014 · 8 citations